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The clinical trial protocol required all participants to start at 2mg regardless of prior GLP-1 experience
doi:10.1016/s0140-6736(19)31266-8 168
Oral formulations were also developed.1,3,5 GLP-1 receptor monoagonists for the treatment of obesity: liraglutide and semaglutide The first molecule to be marketed for the treatment of obesity was liraglutide (LIRA), administered via daily subcutaneous injection, which became available in 2014
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