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In exendin-4 treated control mice (Cre Ex + ), the ratio was strikingly elevated, at 38 3.4%, but remained only 0.9 0.1% in Cre + Ex + mice

The expiration date is set at the point where any of these parameters first falls outside acceptable limits, with a safety margin

While no single head-to-head trial has tested all three compounds against each other, the individual Phase 3 programs provide large-scale, placebo-controlled data that enables meaningful cross-study comparison