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The tripeptide exists intracellularly either in an oxidised glutathione disulphide (GSSG) or reduced state (GSH), and maintaining an optimal GSH:GSSG ratio in the cell is critical for prevention of oxidative damage and for cell survival (Fig
E.JiaoL
Indirectly, yes
In the laboratory, Tau combined with diazepam effectively activate both GABA and Gly receptors, hyperpolarize the cell membrane, reduce neuronal excitability, antagonize the EAA toxicity after CI, and regulate the synthesis and release of EAA and ROS (Wang et al., 2010)
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