Nel 2013, Carlos Lpez-Otn e colleghi hanno pubblicato uno studio sulla rivista Cell intitolato The Hallmarks of Aging (I segni distintivi dellinvecchiamento), identificando nove vie cellulari che regolano linvecchiamento
These alterations preserve approximately 97% sequence homology with native human GLP-1 [18]
REDEFINE 2 Trial Type 2 Diabetes with Obesity The companion REDEFINE 2 trial, also published in 2025, enrolled 1,206 adults with type 2 diabetes and obesity or overweight, demonstrating the combinations efficacy in this more metabolically compromised population: Mean weight loss of 13.7% compared to 3.4% with placebo over 68 weeks 73.5% achieved hemoglobin A1c of 6.5% or less compared to 15.9% with placebo Greater proportions reaching multiple weight thresholds including 5%, 10%, 15%, and 20% reduction Significant glycemic improvement with mean A1c reduction demonstrating disease modification potential Favorable metabolic profile changes including improvements in blood pressure and lipids These findings established that the combination maintains substantial efficacy even in patients with the metabolic dysfunction of established type 2 diabetes, a population often showing reduced response to weight-loss interventions
Back Capozzi, ME, DiMarchi, RD, Tschp, MH, et al (13 June 2019) Targeting the incretin/glucagon system with triagonists to treat diabetes', Endocrine Reviews , 39/5, 719-38
The combination results in synergistic enhancement of tissue regeneration, wound healing, neuroprotective effects, and collagen production
